In fact, the various Botox products – the original BOTOX, DYSPORT, VISTABEL, XEOMIN and others to come – have all been scrutinized by the French drug agency AFSSAPS, and by the European agency. They have obtained prescription authorizations for several disabling diseases, with spectacular results, notably in neurology. The doses used for aesthetic indications are much lower than the usual medical doses. As a result, no serious adverse effects have been described in the treatment of wrinkles with Botox, no allergies have been reported, and efficacy is exceptional. The aim of the treatment is not to paralyze the muscles of expression, but to reduce the tone of these muscles, or hypotonia, which results in a spectacular reduction in wrinkles, while maintaining facial mobility and mimicry. Sessions are carried out 2 or 3 times a year, in an armchair, by surgeons or doctors with precise knowledge of the anatomy of the face and neck. For people who are sensitive to small punctures, an anesthetic cream can be applied to make the session painless.